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1

ChemInform Abstract: The Facile Production of N-Methyl Amino Acids via Oxazolidinones.

Luigi Aurelio, Robert T. C. Brownlee, Andrew B. Hughes, Brad E. Sleebs

Journal:

Year:

2000

File:

PDF, 31 KB

2000

2

ChemInform Abstract: Studies of 2-Substituted 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones as Precursors for the Synthesis of N-Alkyl-β-amino Acids.

Andrew B. Hughes, Brad E. Sleebs

Journal:

Year:

2009

File:

PDF, 46 KB

2009

3

ChemInform Abstract: Recent Advances in Stereoselective Synthesis and Application of β-Amino Acids

Brad E. Sleebs, T. T. Van Nguyen, Andrew B. Hughes

Journal:

Year:

2010

File:

PDF, 17 KB

2010

4

Effective Methods for the Synthesis of N-Methyl β-Amino Acids from All Twenty Common α-Amino Acids Using 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones

Andrew B. Hughes, Brad E. Sleebs

Journal:

Helvetica Chimica Acta

Year:

2006

Language:

english

File:

PDF, 278 KB

english, 2006

5

M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe

Benny J. Evison, Mile Pastuovic, Rebecca A. Bilardi, Robert A. Forrest, Paul P. Pumuye, Brad E. Sleebs, Keith G. Watson, Don R. Phillips, Suzanne M. Cutts

Journal:

Biochemical Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.28 MB

english, 2011

6

Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors

Brad E. Sleebs, George Nikolakopoulos, Ian P. Street, Hendrik Falk, Jonathan B. Baell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 335 KB

english, 2011

7

Corrigendum to “Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors” [Bioorg. Med. Chem. Lett. 21 (2011) 5992–5994]

Brad E. Sleebs, George Nikolakopoulos, Ian P. Street, Hendrik Falk, Jonathan B. Baell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 225 KB

english, 2012

8

Diastereoselective synthesis of highly functionalized β2,2,3-substituted amino acids from 4-substituted-1,3-oxazinan-6-ones

Nghi H. Nguyen, Brad E. Sleebs, Jonathan M. White, Andrew B. Hughes

Journal:

Year:

2012

Language:

english

File:

PDF, 607 KB

english, 2012

9

10.1071/ch99082

Aurelio, Luigi, Brownlee, Robert T. C., Hughes, Andrew B., Sleebs, Brad E.

Journal:

Australian Journal of Chemistry

Year:

2000

Language:

english

File:

PDF, 189 KB

english, 2000

10

Studies of 2-Substituted 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones as Precursors for the Synthesis of N-Alkyl-β-Amino Acids

Hughes, Andrew B., Sleebs, Brad E.

Journal:

Synthetic Communications

Year:

2008

Language:

english

File:

PDF, 318 KB

english, 2008

11

New Anthracenedione Derivatives with Improved Biological Activity by Virtue of Stable Drug−DNA Adduct Formation

Mansour, Oula C., Evison, Benny J., Sleebs, Brad E., Watson, Keith G., Nudelman, Abraham, Rephaeli, Ada, Buck, Damian P., Collins, J. Grant, Bilardi, Rebecca A., Phillips, Don R., Cutts, Suzanne M.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.24 MB

english, 2010

12

Recent Advances in Stereoselective Synthesis and Application of β-Amino Acids

Sleebs, Brad, Van Nguyen, T. T., Hughes, Andrew

Journal:

Organic Preparations and Procedures International

Year:

2009

Language:

english

File:

PDF, 3.82 MB

english, 2009

13

ChemInform Abstract: Diastereoselective Synthesis of Highly Functionalized β 2,2,3 -Substituted Amino Acids from 4-Substituted-1,3-oxazinan-6-ones.

Nguyen, Nghi H., Sleebs, Brad E., White, Jonathan M., Hughes, Andrew B.

Journal:

Year:

2012

File:

PDF, 53 KB

2012

14

Corrigendum to “Diastereoselective synthesis of highly functionalized β2,2,3-substituted amino acids from 4-substituted-1,3-oxazinan-6-ones” [Tetrahedron 68 (2012) 4745–4756]

Nghi H. Nguyen, Brad E. Sleebs, Jonathan M. White, Andrew B. Hughes

Journal:

Year:

2012

Language:

english

File:

PDF, 72 KB

english, 2012

15

Structure-guided design of a selective BCL-XL inhibitor

Lessene, Guillaume, Czabotar, Peter E, Sleebs, Brad E, Zobel, Kerry, Lowes, Kym N, Adams, Jerry M, Baell, Jonathan B, Colman, Peter M, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Gibbons, P

Journal:

Nature Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

16

Diastereoselective synthesis of cyclic β2,3-amino acids utilizing 4-substituted-1,3-oxazinan-6-ones

Sleebs, Brad E., Nguyen, Nghi H., Hughes, Andrew B.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.40 MB

english, 2013

17

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X L

Sleebs, Brad E., Kersten, Wilhemus J. A., Kulasegaram, Sanji, Nikolakopoulos, George, Hatzis, Effie, Moss, Rebecca M., Parisot, John P., Yang, Hong, Czabotar, Peter E., Fairlie, W. Douglas, Lee, Erinn

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.94 MB

english, 2013

18

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Sleebs, Brad E., Czabotar, Peter E., Fairbrother, Wayne J., Fairlie, W. Douglas, Flygare, John A., Huang, David C. S., Kersten, Wilhelmus J. A., Koehler, Michael F. T., Lessene, Guillaume, Lowes, Kym,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.81 MB

english, 2011

19

Diastereoselective Synthesis of α-Methyl and α-Hydroxy-β-Amino Acids via 4-Substituted-1,3-Oxazinan-6-ones

Sleebs, Brad E., Hughes, Andrew B.

Journal:

Journal of Organic Chemistry

Year:

2007

Language:

english

File:

PDF, 232 KB

english, 2007

20

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

Koehler, Michael F. T., Bergeron, Philippe, Choo, Edna F., Lau, Kevin, Ndubaku, Chudi, Dudley, Danette, Gibbons, Paul, Sleebs, Brad E., Rye, Carl S., Nikolakopoulos, George, Bui, Chinh, Kulasegaram, S

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.12 MB

english, 2014

21

Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P. falciparum and P. vivax

Sleebs, Brad E., Gazdik, Michelle, O’Neill, Matthew T., Rajasekaran, Pravin, Lopaticki, Sash, Lackovic, Kurt, Lowes, Kym, Smith, Brian J., Cowman, Alan F., Boddey, Justin A.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 708 KB

english, 2014

22

Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors

Sleebs, Brad E., Levit, Alla, Street, Ian P., Falk, Hendrik, Hammonds, Tim, Wong, Ai Ching, Charles, Mark D., Olson, Michael F., Baell, Jonathan B.

Journal:

Year:

2011

Language:

english

File:

PDF, 156 KB

english, 2011

23

Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors

Sleebs, Brad E., Ganame, Danny, Levit, Alla, Street, Ian P., Gregg, Alison, Falk, Hendrik, Baell, Jonathan B.

Journal:

Year:

2011

Language:

english

File:

PDF, 114 KB

english, 2011

24

Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome

Boddey, Justin A., Carvalho, Teresa G., Hodder, Anthony N., Sargeant, Tobias J., Sleebs, Brad E., Marapana, Danushka, Lopaticki, Sash, Nebl, Thomas, Cowman, Alan F.

Journal:

Year:

2013

Language:

english

File:

PDF, 18.15 MB

english, 2013

25

ChemInform Abstract: Stereoselective Synthesis and Application of β-Amino Ketones

Nguyen, Nghi H., Hughes, Andrew B., Sleebs, Brad E.

Journal:

Year:

2014

File:

PDF, 17 KB

2014

26

The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V

Gazdik, Michelle, O'Neill, Matthew T., Lopaticki, Sash, Lowes, Kym N., Smith, Brian J., Cowman, Alan F., Boddey, Justin A., Sleebs, Brad E.

Journal:

Year:

2015

Language:

english

File:

PDF, 523 KB

english, 2015

27

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Sleebs, Brad E., Lopaticki, Sash, Marapana, Danushka S., O'Neill, Matthew T., Rajasekaran, Pravin, Gazdik, Michelle, Günther, Svenja, Whitehead, Lachlan W., Lowes, Kym N., Barfod, Lea, Hviid, Lars, Sh

Journal:

Year:

2014

Language:

english

File:

PDF, 1.91 MB

english, 2014

28

Synthesis of N-Cbz-Substituted β3-Amino Ketones Utilizing 4-Substituted 1,3-Oxazinan-6-ones

Sleebs, Brad, Nguyen, Nghi, Hughes, Andrew

Journal:

Year:

2013

Language:

english

File:

PDF, 211 KB

english, 2013

29

A Mild Multistep Conversion of N-Protected α-Amino Acids into N-Protected β3-Amino Acids Utilizing the Nef Reaction

Sleebs, Brad, Nguyen, Nghi, Hughes, Andrew

Journal:

Year:

2013

Language:

english

File:

PDF, 201 KB

english, 2013

30

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

Hodder, Anthony N, Sleebs, Brad E, Czabotar, Peter E, Gazdik, Michelle, Xu, Yibin, O'Neill, Matthew T, Lopaticki, Sash, Nebl, Thomas, Triglia, Tony, Smith, Brian J, Lowes, Kym, Boddey, Justin A, Cowma

Journal:

Nature Structural and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 2.06 MB

english, 2015

31

De Novo Synthesis of a Potent LIMK1 Inhibitor

Sleebs, Brad, Street, Ian, Bu, Xian, Baell, Jonathan

Journal:

Year:

2010

Language:

english

File:

PDF, 123 KB

english, 2010

32

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum

Wilson, Danny W, Goodman, Christopher D, Sleebs, Brad E, Weiss, Greta E, de Jong, Nienke WM, Angrisano, Fiona, Langer, Christine, Baum, Jake, Crabb, Brendan S, Gilson, Paul R, McFadden, Geoffrey I, Be

Journal:

Year:

2015

Language:

english

File:

PDF, 2.89 MB

english, 2015

33

Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

Gazdik, Michelle, Jarman, Kate E., O’Neill, Matthew T., Hodder, Anthony N., Lowes, Kym N., Jousset Sabroux, Helene, Cowman, Alan F., Boddey, Justin A., Sleebs, Brad E.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.79 MB

english, 2016

34

Reversible and formaldehyde-mediated covalent binding of WEHI-150 to DNA

Konda, Shyam K, Kelso, Celine, Pumuye, Paul, Medan, Jelena, Sleebs, Brad E., Cutts, Suzanne M, Phillips, Don R, Collins, John Grant

Journal:

Organic & Biomolecular Chemistry

Year:

2016

Language:

english

File:

PDF, 1.85 MB

english, 2016

35

Synthesis of amino heterocycle aspartyl protease inhibitors

Chambers, Rachel K., Khan, Tanweer A., Olsen, David B., Sleebs, Brad E.

Journal:

Organic & Biomolecular Chemistry

Year:

2016

Language:

english

File:

PDF, 1.42 MB

english, 2016

36

Mitoxantrone, More than Just Another Topoisomerase II Poison

Evison, Benny J., Sleebs, Brad E., Watson, Keith G., Phillips, Don R., Cutts, Suzanne M.

Journal:

Medicinal Research Reviews

Year:

2016

Language:

english

File:

PDF, 1.05 MB

english, 2016

37

ChemInform Abstract: A Mild Multistep Conversion of N-Protected α-Amino Acids into N-Protected β 3 -Amino Acids Utilizing the Nef Reaction.

Sleebs, Brad E., Nguyen, Nghi H., Hughes, Andrew B.

Journal:

Year:

2013

File:

PDF, 36 KB

2013

38

ChemInform Abstract: Synthesis of N-Cbz-Substituted β 3 -Amino Ketones Utilizing 4-Substituted 1,3-Oxazinan-6-ones.

Sleebs, Brad E., Nguyen, Nghi H., Hughes, Andrew B.

Journal:

Year:

2013

File:

PDF, 33 KB

2013

39

Isolation and structural analysis of the covalent adduct formed between a bis-amino mitoxantrone analogue and DNA: a pathway to major–minor groove cross-linked adducts

Konda, Shyam K., Kelso, Celine, Medan, Jelena, Sleebs, Brad E., Phillips, Don R., Cutts, Suzanne M., Collins, J. Grant

Journal:

Organic & Biomolecular Chemistry

Year:

2016

Language:

english

File:

PDF, 1.93 MB

english, 2016

40

Analysis of Ca 2+ mediated signalling regulating Toxoplasma infectivity reveals complex relationships between key molecules

Stewart, Rebecca J., Whitehead, Lachlan, Nijagal, Brunda, Sleebs, Brad E., Lessene, Guillaume, McConville, Malcolm J, Rogers, Kelly L., Tonkin, Christopher J.

Journal:

Cellular Microbiology

Year:

2016

Language:

english

File:

PDF, 4.58 MB

english, 2016

41

Synthesis of New β-Amino Acids via 5-Oxazolidinones and the Arndt–Eistert Procedure

Hughes, Andrew B., Sleebs, Brad E.

Journal:

Australian Journal of Chemistry

Year:

2005

Language:

english

File:

PDF, 231 KB

english, 2005

42

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

Wong, Wilson, Bai, Xiao-Chen, Sleebs, Brad E., Triglia, Tony, Brown, Alan, Thompson, Jennifer K., Jackson, Katherine E., Hanssen, Eric, Marapana, Danushka S., Fernandez, Israel S., Ralph, Stuart A., C

Journal:

Nature Microbiology

Year:

2017

Language:

english

File:

PDF, 3.57 MB

english, 2017

43

Exploitation of the Arndt-Eistert Homologation of N-Methyl-�-Amino Acids for Concomitant Ester and N-Methyl Peptide Formation

Hughes, Andrew B., Sleebs, Brad E.

Journal:

Australian Journal of Chemistry

Year:

2008

Language:

english

File:

PDF, 284 KB

english, 2008

44

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Brouwer, Jason M., Lan, Ping, Cowan, Angus D., Bernardini, Jonathan P., Birkinshaw, Richard W., van Delft, Mark F., Sleebs, Brad E., Robin, Adeline Y., Wardak, Ahmad, Tan, Iris K., Reljic, Boris, Lee,

Journal:

Year:

2017

Language:

english

File:

PDF, 5.06 MB

english, 2017

45

ChemInform Abstract: Synthesis of Amino Heterocycle Aspartyl Protease Inhibitors

Chambers, Rachel K., Khan, Tanweer A., Olsen, David B., Sleebs, Brad E.

Journal:

Year:

2016

File:

PDF, 14 KB

2016

46

HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators

Cardno, Tony S., Shimaki, Yosuke, Sleebs, Brad E., Lackovic, Kurt, Parisot, John P., Moss, Rebecca M., Crowe-McAuliffe, Caillan, Mathew, Suneeth F., Edgar, Christina D., Kleffmann, Torsten, Tate, Warr

Journal:

Year:

2015

Language:

english

File:

PDF, 985 KB

english, 2015

47

An appraisal of natural products active against parasitic nematodes of animals

Garcia-Bustos, Jose F., Sleebs, Brad E., Gasser, Robin B.

Journal:

Parasites & Vectors

Year:

2019

Language:

english

File:

PDF, 1.59 MB

english, 2019

48

The development process for discovery and clinical advancement of modern antimalarials

Ashton, Trent D, Devine, Shane M., Moehrle, Joerg J., Laleu, Benoît, Burrows, Jeremy N., Charman, Susan A., Creek, Darren John, Sleebs, Brad E.

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.47 MB

english, 2019

49

Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes

Jennison, Charlie, Lucantoni, Leonardo, O’Neill, Matthew T., McConville, Robyn, Erickson, Sara M., Cowman, Alan F., Sleebs, Brad E., Avery, Vicky M., Boddey, Justin A.

Journal:

Year:

2019

File:

PDF, 2.81 MB

2019

50

Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features

Pumuye, Paul P., Evison, Benny J., Konda, Shyam K., Collins, J. Grant, Kelso, Celine, Medan, Jelena, Sleebs, Brad E., Watson, Keith, Phillips, Don R., Cutts, Suzanne M.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2019

File:

PDF, 4.67 MB

2019